Subjects who smoked their first cigarette between 31 and 60 minutes after waking up were more than 30% more likely to develop lung cancer; the odds increased to nearly 80% for those who smoked in their first half-hour awake. For head and neck cancers, subjects were more than 40% more likely if they indulged in the 31-60 minute window, and nearly 60% more likely for those who smoked in their first half-hour awake.
The half-life of nicotine is relatively short- only two hours - so after six or eight hours of sleep, your body has gotten rid of nearly all of the nicotine you've inhaled the day before. There's very little left in the body in the morning and the receptors in the brain are crying out for more nicotine. Those who are the most dependent need that cigarette earlier, and often smoke more cigarettes throughout the day, more intensely.
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